Patients taking long-term opioids produce antibodies against the drugs

Scientists have discovered that a majority of back-pain patients they tested who were taking opioid painkillers produced anti-opioid antibodies. These antibodies may contribute to some of the negative side effects of long-term opioid use.

The researchers discovered antibodies against protein-bound opioids in 10 of 19 patients who took opioids to treat chronic lower back pain. Those who took higher doses of opioids had a stronger antibody response. A control group of three patients who did not take opioids for their back pain had only very low levels of anti-opioid antibodies.

For this initial study, the researchers could only identify three patients with chronic pain who had not previously taken opioids, even after a months-long radio and print recruiting campaign. This challenge was an indication of the ubiquity of these drugs, despite evidence that they are riskier options than non-opioid painkillers for treating chronic pain.

Patients who take opioids for extended periods can develop serious side effects, including hyperalgesia, a sensitive, painful response to harmless touch.

Chiropractic care for back pain is an effective alternative to opioid use. Chiropractors are specially trained in alleviating back pain without resorting to opioids or surgery, but with gentle, hands-on treatment.

Presented as a service to the community by: Union County Chiropractic Clinic, 110 Skyline Drive, Maynardville, TN (865) 992-7000 www.unioncountychiropractic.com.