Anticonvulsant Drugs Ineffective for Low Back Pain and Can Cause Harm, Despite Increased Prescribing

Anticonvulsant drugs are increasingly being used to treat low back pain, but a study in CMAJ (Canadian Medical Association Journal) finds they are ineffective and can have adverse effects. Clinically, the prescription of anticonvulsants for back and neck pain, including radicular pain in primary care, has increased by 535% in the last 10 years. Low back pain affects millions of people and is the number one cause of disability.

Clinical practice guidelines usually recommend nonpharmacologic treatments and nonopioid pain relievers rather than stronger analgesics such as anticonvulsants. The study findings are based on high- and moderate-quality evidence from nine placebo-controlled randomized trials that found a lack of evidence of benefit from anticonvulsants and more negative results from some of these drugs.

“We have shown, with mostly high- and moderate-quality evidence, that common anticonvulsants are ineffective for chronic low back pain and lumbar radicular pain, and are accompanied by increased risk of adverse events,” write the authors.

These findings support recent guidelines from the United States and the United Kingdom that do not recommend the use of anticonvulsants.

A most promising solution to low back pain: hands-on care by a chiropractor, a doctor of chiropractic, an expert in diagnosing and relieving lower back pain.

Presented as a service to the community by: Union County Chiropractic Clinic, 110 Skyline Drive, Maynardville, TN (865) 992-7000 www.unioncountychiropractic.com